Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases
MR de Vries, MM Ewing, RCM de Jong… - Journal of Internal …, 2021 - Wiley Online Library
Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …
Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation
J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Chronic inflammatory diseases include cardiovascular disease (CVD),
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …
[PDF][PDF] Immunoglobulin G1 antibodies against phosphorylcholine are associated with protection in systemic lupus erythematosus and atherosclerosis: Potential …
D Thiagarajan, R Fiskesund, A Frostegård… - ACR open …, 2020 - Wiley Online Library
Objective Immunoglobulin M antibodies against phosphorylcholine (anti‐PC s) may be
protective in atherosclerosis, cardiovascular disease (CVD), and systemic lupus …
protective in atherosclerosis, cardiovascular disease (CVD), and systemic lupus …
[HTML][HTML] Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases
J Frostegård - Metabolites, 2023 - mdpi.com
Atherosclerosis and its main consequence, cardiovascular disease (CVD) are nowadays
regarded as chronic inflammatory disease conditions, and CVD is the main cause of death …
regarded as chronic inflammatory disease conditions, and CVD is the main cause of death …
Natural antibodies against phosphorylcholine in cardiovascular disease
U De Faire, J Frostegård - Annals of the New York Academy of …, 2009 - Wiley Online Library
Atherosclerosis is a chronic inflammatory disease characterized by the presence of activated
immune‐competent cells in the lesions, producing mainly proinflammatory cytokines …
immune‐competent cells in the lesions, producing mainly proinflammatory cytokines …
Phosphorylcholine-targeting immunization reduces atherosclerosis
G Caligiuri, J Khallou-Laschet, M Vandaele… - Journal of the American …, 2007 - jacc.org
Objectives: The present study evaluated the effect of phosphorylcholine (PC) immunization
on the extent of experimental atherosclerosis. Background: Immunization against oxidized …
on the extent of experimental atherosclerosis. Background: Immunization against oxidized …
Low levels of natural IgM antibodies against phosphorylcholine are independently associated with vascular remodeling in patients with coronary artery disease
CA Gleissner, C Erbel, J Haeussler… - Clinical Research in …, 2015 - Springer
Low anti-phosphorylcholine (PC) IgM plasma levels have been associated with increased
incidence of adverse events in coronary artery disease (CAD). The underlying mechanisms …
incidence of adverse events in coronary artery disease (CAD). The underlying mechanisms …
[HTML][HTML] IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with …
R Fiskesund, J Su, I Bulatovic, M Vikström… - Results in …, 2012 - Elsevier
Background We have reported that anti-phosphorylcholine (anti-PC) IgM is a protection
marker for human cardiovascular disease (CVD) and atherosclerosis. We here investigate …
marker for human cardiovascular disease (CVD) and atherosclerosis. We here investigate …
Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
J Frostegård - Clinical immunology, 2010 - Elsevier
Atherosclerosis is an inflammatory condition characterised by an abundance of activated
immunocompetent cells in plaques which cause cardiovascular disease (CVD) when they …
immunocompetent cells in plaques which cause cardiovascular disease (CVD) when they …
Levels of natural IgM antibodies against phosphorylcholine in healthy individuals and in patients undergoing isolated limb perfusion
ND Padilla, C Ciurana, J van Oers, AC Ogilvie… - Journal of …, 2004 - Elsevier
Natural IgM antibodies against phosphorylcholine (anti-Pc IgM) resemble C-reactive protein
(CRP) regarding specificity and have gained increasing attention because of their supposed …
(CRP) regarding specificity and have gained increasing attention because of their supposed …