[HTML][HTML] miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation
A Ghazaryan, JA Wallace, WW Tang, C Barba… - Frontiers in …, 2023 - frontiersin.org
Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by
uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated …
uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated …
[HTML][HTML] miRNAs in acute myeloid leukemia
Q Liao, B Wang, X Li, G Jiang - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small, non-coding RNAs found throughout the eukaryotes that
control the expression of a number of genes involved in commitment and differentiation of …
control the expression of a number of genes involved in commitment and differentiation of …
[HTML][HTML] miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …
generated a prognostic LSC-associated miRNA signature derived from functionally …
[HTML][HTML] Molecular dysfunctions in acute myeloid leukemia revealed by integrated analysis of microRNA and transcription factor
XC Lin, Y Xu, GP Sun, JL Wen… - International …, 2016 - spandidos-publications.com
Acute myeloid leukemia (AML) is a heterogenic hematological malignancy with
pathogenesis that has yet to be elucidated. MicroRNAs (miRNAs) and transcription factors …
pathogenesis that has yet to be elucidated. MicroRNAs (miRNAs) and transcription factors …
[HTML][HTML] DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid …
S Ye, F Xiong, X He, Y Yuan, D Li, D Ye, L Shi, Z Lin… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: microRNAs (miRNAs) are frequently deregulated and play important roles in the
pathogenesis and progression of acute myeloid leukemia (AML). miR-182 functions as an …
pathogenesis and progression of acute myeloid leukemia (AML). miR-182 functions as an …
MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis
Point mutations in the seed sequence of miR-142-3p are present in a subset of acute
myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show …
myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show …
[HTML][HTML] Investigating the microRNA-mRNA regulatory network in acute myeloid leukemia
H Zhang, C Zhang, R Feng, H Zhang… - Oncology …, 2017 - spandidos-publications.com
Acute myeloid leukemia (AML) is a common myelogenous malignancy in adults that is often
characterized by disease relapse. The pathophysiological mechanism of AML has not yet …
characterized by disease relapse. The pathophysiological mechanism of AML has not yet …
OncomiR or antioncomiR: Role of miRNAs in acute myeloid leukemia
C He, B Luo, N Jiang, Y Liang, Y He, J Zeng… - Leukemia & …, 2019 - Taylor & Francis
Abstract Acute Myeloid Leukemia (AML) is a hematopoietic progenitor/stem cell disorder in
which neoplastic myeloblasts are stopped at an immature stage of differentiation and lost the …
which neoplastic myeloblasts are stopped at an immature stage of differentiation and lost the …
Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia
J Ye, D Luo, J Yu, S Zhu - Hematology, 2019 - Taylor & Francis
Objectives: Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent
hematological malignancy. Studies have shown an association between microRNAs and …
hematological malignancy. Studies have shown an association between microRNAs and …
[HTML][HTML] Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation
Acute myeloid leukemia (AML) is an aggressive blood cancer with poor clinical outcomes.
Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a …
Emerging data suggest that mitochondrial oxidative phosphorylation (mtOXPHOS) plays a …