Cocaine is a highly addictive stimulant and a well-known drug, with multiple effects on
physiology. Cocaine can have direct effects on all cell types in the brain, including microglia …

Exosomes are small extracellular vesicles that have emerged as an important tool for
intercellular communication. In the central nervous system, exosomes can mediate glia and …

Background Microglia are important myeloid cells present in the brain parenchyma that
serve a surveillance function in the central nervous system. Microglial cell activation results …

Alteration of glutamatergic synaptic plasticity in the Nucleus Accumbens (NAc) has been
implicated in cocaine-seeking behaviors. Astroglial mechanisms for maintaining …

Substance use disorder (SUD) is a growing health problem that affects several millions of
people worldwide, resulting in negative socioeconomic impacts and increased health care …

Abstract Background The United States is currently facing an opioid crisis. Novel tools to
better comprehend dynamic molecular changes in the brain associated with the opioid …

Cocaine, a commonly used drug of abuse, has been shown to cause neuropathological
dysfunction and damage in the human brain. However, the role of autophagy in this process …

Cocaine is known to induce inflammation, thereby contributing in part, to the pathogenesis of
neurodegeneration. A recent study from our lab has revealed a link between …

Exosomes between 40 and 200 nm in size constitute the smallest subgroup of extracellular
vesicles. These bioactive vesicles secreted by cells play an active role in intercellular cargo …

Extracellular vesicles (EVs) are small vesicles secreted by cells and are known to carry sub-
cellular components including microRNA, proteins, and lipids. Due to their ability to transport …