As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Continued work to elucidate mechanisms by which fibrin (ogen), factor XIII, and red blood
cells contribute to venous thrombus formation, structure, and stability may expose novel …

Cardiovascular disease is the leading cause of death and disability worldwide. Among
cardiovascular causes of death, venous thrombosis (VT) is ranked third most common in the …

Fibrinogen molecules are comprised of two sets of disulfide‐bridged Aα‐, Bβ‐, and γ‐
chains. Each molecule contains two outer D domains connected to a central E domain by a …

Fibrinogen and factor XIII are two essential proteins that are involved directly in fibrin gel
formation as the final step of a sequence of reactions triggered by a procoagulant stimulus …

Recent data indicate an important contribution of coagulation factor (F) XII to in vivo
thrombus formation. Because fibrin structure plays a key role in clot stability and thrombosis …

Arterial and venous thromboses are major contributors to coagulation-associated morbidity
and mortality. Greater understanding of mechanisms leading to thrombus formation and …

Venous thrombi, fibrin-and rbc-rich clots triggered by inflammation and blood stasis, underlie
devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition …

Plasma factor XIII (FXIII) is a tetrameric zymogen consisting of two potentially active A
subunits (FXIII-A) and two carrier/inhibitory B subunits (FXIII-B). In the final phase of the …

Blood coagulation is a highly regulated process involving interactions between platelets,
plasma coagulation factors, and the vessel wall. During coagulation in vivo, fibrin formation …