What happens in early, still undetectable human malignancies is unknown because direct
observations are impractical. Here we present and validate a'Big Bang'model, whereby …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas
(malignant) remain largely undetermined. Using multi-region genome and exome …

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention. Here we model occult preneoplasia by …

Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of
genomic data in the light of cancer evolution remains challenging. Here we demonstrate that …

Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral
evolution; however, intratumor heterogeneity in colorectal precancerous lesions has been …

Every cancer originates from a single cell. During expansion of the neoplastic cell
population, individual cells acquire genetic and phenotypic differences from each other …

Given the implications of tumor dynamics for precision medicine, there is a need to
systematically characterize the mode of evolution across diverse solid tumor types. In …