[HTML][HTML] Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
[HTML][HTML] Integrin targeted therapeutics
M Millard, S Odde, N Neamati - Theranostics, 2011 - ncbi.nlm.nih.gov
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors,
adhesion molecules and signal transduction platforms in a multitude of biological processes …
adhesion molecules and signal transduction platforms in a multitude of biological processes …
[HTML][HTML] Why integrin as a primary target for imaging and therapy
Integrin-mediated cell adhesion is involved in many essential normal cellular and
pathological functions including cell survival, growth, differentiation, migration, inflammatory …
pathological functions including cell survival, growth, differentiation, migration, inflammatory …
Integrins as therapeutic targets
SL Goodman, M Picard - Trends in pharmacological sciences, 2012 - cell.com
Integrins are a large family of molecules that are central regulators in multicellular biology.
They orchestrate cell–cell and cell–extracellular matrix (ECM) adhesive interactions from …
They orchestrate cell–cell and cell–extracellular matrix (ECM) adhesive interactions from …
Integrins as therapeutic targets: lessons and opportunities
The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …
regulation of cell growth and function. The identification of key roles for integrins in a diverse …
Integrin modulators: a patent review
TG Kapp, F Rechenmacher, TR Sobahi… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Integrins are heterodimeric cell surface receptors, which enable adhesion,
proliferation, and migration of cells by recognizing binding motifs in extracellular matrix …
proliferation, and migration of cells by recognizing binding motifs in extracellular matrix …
[HTML][HTML] Integrins as therapeutic targets: successes and cancers
S Raab-Westphal, JF Marshall, SL Goodman - Cancers, 2017 - mdpi.com
Integrins are transmembrane receptors that are central to the biology of many human
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …
[HTML][HTML] Targeting integrins for cancer therapy-disappointments and opportunities
C Bergonzini, K Kroese, AJM Zweemer… - Frontiers in Cell and …, 2022 - frontiersin.org
Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities
F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate the interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …
extracellular matrix (ECM) and cells and are essential for cell migration and the …
Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications
SA Mousa - Current opinion in chemical biology, 2002 - Elsevier
The role of integrin and extracellular matrix proteins in various pathological processes
(including angiogenesis, thrombosis, apoptosis and cell migration and proliferation), leading …
(including angiogenesis, thrombosis, apoptosis and cell migration and proliferation), leading …