Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet
Selection of human cytomegalovirus variants in the presence of ganciclovir or foscarnet led
to 18 DNA polymerase mutations, 14 of which had not been previously studied. Using …
to 18 DNA polymerase mutations, 14 of which had not been previously studied. Using …
Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy
S Chou - Journal of clinical virology, 2011 - Elsevier
BACKGROUND: Cytomegalovirus UL54 DNA polymerase mutations observed in clinical
specimens are of diagnostic significance if confirmed to affect antiviral drug susceptibility …
specimens are of diagnostic significance if confirmed to affect antiviral drug susceptibility …
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene
S Chou - Antiviral research, 2017 - Elsevier
Human cytomegalovirus UL54 DNA polymerase gene mutations that confer foscarnet
resistance in clinical practice typically cluster in the amino terminal 2, palm and finger …
resistance in clinical practice typically cluster in the amino terminal 2, palm and finger …
Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
S Chou, GI Marousek, LC Van Wechel… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical
specimens showed that T813S and G841A each conferred foscarnet resistance and …
specimens showed that T813S and G841A each conferred foscarnet resistance and …
New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure
C Gilbert, G Boivin - Antimicrobial agents and chemotherapy, 2005 - Am Soc Microbiol
We developed a new reporter cell line for human cytomegalovirus (HCMV) drug
susceptibility testing. This cell line was obtained by incorporating the luciferase reporter …
susceptibility testing. This cell line was obtained by incorporating the luciferase reporter …
[HTML][HTML] High impact of an expanded restriction fragment length polymorphism assay on detection of ganciclovir-resistant UL97 mutants of human cytomegalovirus
T Eckle, G Jahn, K Hamprecht - Antimicrobial agents and …, 2003 - Am Soc Microbiol
The advent of highly active antiretroviral therapy for human immunodeficiency virus-infected
individuals has reduced the emergence of ganciclovir (GCV)-resistant human …
individuals has reduced the emergence of ganciclovir (GCV)-resistant human …
A Novel Mutation in the Ul54 Gene of Human Cytomegalovirus Isolates that Confers Resistance to Foscarnet
A Ducancelle, G Champier, S Alain, F Petit… - 2006 - journals.sagepub.com
Foscarnet is currently licensed for the treatment of human cytomegalovirus (HCMV)
infection. Mutations proven to confer resistance to foscarnet have mostly been mapped to …
infection. Mutations proven to confer resistance to foscarnet have mostly been mapped to …
Aciclovir selects for ganciclovir‐cross‐resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein
D Michel, S Höhn, T Haller, D Jun… - Journal of medical …, 2001 - Wiley Online Library
Phenotypically, ganciclovir‐resistant human cytomegalovirus strains could be selected by
aciclovir as effectively as by ganciclovir in vitro. Three clinical human cytomegalovirus …
aciclovir as effectively as by ganciclovir in vitro. Three clinical human cytomegalovirus …
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial
S Chou, G Boivin, J Ives, R Elston - The Journal of infectious …, 2014 - academic.oup.com
Background. In a large randomized trial comparing oral valganciclovir and intravenous
ganciclovir for treatment of cytomegalovirus disease in solid organ transplantation …
ganciclovir for treatment of cytomegalovirus disease in solid organ transplantation …
Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance
S Chou - Antimicrobial agents and chemotherapy, 2010 - Am Soc Microbiol
ABSTRACT A strain of human cytomegalovirus, T2211, modified from standard laboratory
strain AD169 to contain a secreted alkaline phosphatase reporter gene for rapid viral …
strain AD169 to contain a secreted alkaline phosphatase reporter gene for rapid viral …