Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all
macromolecular components during each passage through the cell cycle. It is therefore not …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Cellular metabolism is at the foundation of all biological activities. The catabolic processes
that support cellular bioenergetics and survival have been well studied. By contrast, how …

Stem and progenitor cells proliferate and give rise to other types of cells through
differentiation. Deregulation of this process can lead to many diseases including cancer …

Cancer cells exhibit profound metabolic alterations, allowing them to fulfill the metabolic
needs that come with increased proliferation and additional facets of malignancy. Such a …

Cancer metabolism has long been equated with aerobic glycolysis, seen by early
biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures …

ABSTRACT A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated
once cells have accumulated alterations in signaling pathways that control metabolism and …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Abstract Development of malignancy is accompanied by a complete metabolic
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …