Decellularization of tissues and organs has recently become a promising approach in tissue
engineering and regenerative medicine to circumvent the challenges of organ donation and …

Bioengineering a functional organ holds great potential to overcome the current gap
between the organ need and shortage of available organs. Whole organ decellularization …

Cardiovascular disease (CVD) is one of the leading causes of death in the Western world.
The replacement of damaged vessels and valves has been practiced since the 1950's …

Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

The prevalent challenge facing tissue engineering today is the lack of adequate
vascularization to support the growth, function, and viability of tissue substitutes that require …

The ability to understand and regulate human vasculature development and differentiation
has the potential to benefit patients suffering from a variety of ailments, including …

Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

Due to poor vessel quality in patients with cardiovascular diseases, there has been an
increased demand for small-diameter tissue-engineered blood vessels that can be used as …

Decellularized organs and tissues are effectively utilized in a diversity of regenerative
medicine purposes, and the decellularization approaches employed differ as broadly as the …

Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …