Chemical-induced neurotoxicity is increasingly recognized to accelerate the development of
neurodegenerative disorders (NDs), which pose an increasing health burden to society …

Environmental exposure to arsenic has been profoundly associated with chronic systemic
disorders, such as neurodegeneration, in both experimental models and clinical studies …

Alzheimer's disease (AD) is presented as an age-related neurodegenerative disease with
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …

Increasing evidence indicates that nobiletin (NOB) is a promising neuroprotective agent.
Astrocyte activation plays a key role in neurodegenerative disorders. Thus, this study aims to …

Background Demethylnobiletin (DN), with a variety of biological activities, is a polymethoxy‐
flavanone (PMF) found in citrus. In the present study, we explored the biological activities …

Background: Nobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit
cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and …

Inhibition of nitric oxide synthases (NOSs) shows promise to halt the progression of
neurodegenerative diseases. The present study was designed to explore whether botanical …

Astrocytes are the major glial cells in the human brain and provide crucial metabolic and
trophic support to neurons. The amyloid-β peptide (Aβ) alter the morphological and …

Ischemic stroke is a severe neurological disorder with a high prevalence rate in developed
countries. It is characterized by permanent or transient cerebral ischemia and it activates …

Background Nobiletin (NOB), an active natural flavonoid component of citrus, is used in
Traditional Chinese Medicine for its anti-inflammatory activity, but its efficacy in cerebral …