Timolol maleate is a non‐selective β‐adrenoceptor antagonist currently used mainly as an
ocular preparation for the treatment of glaucoma and ocular hypertension. Despite the …

Background. To investigate the pharmacological basis of systemic side effects of ophthalmic
timolol, we estimated the systemic bioavailability of 0.5% timolol eyedrops and compared …

Glaucoma is a common eye disease that can cause irreversible blindness if not diagnosed
and treated in the early stages of progression. This disease is often, albeit not always …

Timolol is a beta adrenergic antagonist in 0.25% or 0.5% eyedrop solution for glaucoma. In
a double‐blind crossover study in healthy males we measured systemic beta blockade …

Purpose: The objective of this study was to compare plasma concentrations of timolol
following multiple dosing of the therapeutic regimens of timolol maleate ophthalmic gel …

Introduction: It is generally believed that topical administration of eye drops safeguards
against harmful systemic effects. However, about 80% of the drug in the ophthalmic products …

Synopsis: Timolol maleate 1 is a nonselective β-blocking drug used for the topical treatment
of increased intraocular pressure in patients with chronic open angle glaucoma. In …

Purpose: The objective of this randomized, double‐blind, controlled crossover trial was to
compare 0.1% timolol hydrogel formulation eyedrops with 0.5% timolol aqueous solution in …

Background: Systemic adverse effects of ocular timolol therapy are due to absorption of the
drug from the eye into the systemic circulation. Elderly patients are frequently more …

Topically applied ophthalmic drugs can occasionally produce adverse systemic effects due
to systemic absorption of the drug or impediment of the drug's metabolism. Increasing …