Soluble LOX‐1: a novel biomarker in patients with coronary artery disease, stroke, and acute aortic dissection?

A Hofmann, C Brunssen, S Wolk, C Reeps… - Journal of the …, 2020 - Am Heart Assoc
Cardiovascular diseases are the leading cause of death worldwide. Approximately 85% of
all deaths from cardiovascular disease are due to acute myocardial infarction (AMI) and …

LOX-1 and atherosclerosis: proof of concept in LOX-1–knockout mice

H Morawietz - Circulation research, 2007 - Am Heart Assoc
An increased plasma level of low-density lipoprotein (LDL) is a well-known risk factor for
endothelial dysfunction and atherosclerosis. 1 The proatherosclerotic potential of LDL may …

Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

K Tian, S Ogura, PJ Little, S Xu… - Annals of the New York …, 2019 - Wiley Online Library
Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …

LOX-1 in atherosclerotic disease

T Sawamura, I Wakabayashi, T Okamura - Clinica Chimica Acta, 2015 - Elsevier
Oxidized low-density lipoprotein (LDL) exhibits various biological activities and accumulates
in atheromas. LOX-1 (lectin-like oxidized LDL receptor) is the receptor that mediates …

LOX-1 the multifunctional receptor underlying cardiovascular dysfunction

S Ogura, A Kakino, Y Sato, Y Fujita, S Iwamoto… - Circulation …, 2009 - jstage.jst.go.jp
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …

LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation

NVK Pothineni, SK Karathanasis, Z Ding… - Journal of the American …, 2017 - jacc.org
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …

[HTML][HTML] The discovery of LOX-1, its ligands and clinical significance

R Yoshimoto, Y Fujita, A Kakino, S Iwamoto… - … drugs and therapy, 2011 - Springer
LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …

Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions

DY Li, HJ Chen, ED Staples, K Ozaki… - Journal of …, 2002 - journals.sagepub.com
Background: Lectin-like oxidized LDL receptor-I (LOX-1), a novel receptor for oxidized low-
density lipoprotein, mediates oxidized low-density lipoprotein-induced apoptosis of …

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …