Tumour necrosis factor (TNF) plays an important role in the pathogenesis of immune-
mediated inflammatory diseases (IMIDs). TNF inhibition results in down-regulation of …

The complex pathogenesis of immune-mediated inflammatory diseases (IMIDs) has been
extensively investigated and dysregulation of cytokines, such as tumour necrosis factor …

Ongoing progress in understanding the pathogenic mechanisms regulating various immune-
mediated and inflammatory diseases, as well as the availability of innovative …

Adalimumab (Humira®) is a human monoclonal TNF-α antibody that blocks the effects of
TNF-α. It is administered by subcutaneous injection. It has been approved alone or in …

Tumor necrosis factor (TNF) has been implicated in a number of arthritic disease states,
including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Adalimumab is …

Introduction: In the last couple of years, the number of patients with chronic inflammatory
rheumatic diseases being treated with TNF α antagonist has increased dramatically …

Introduction: Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by
a relapsing-remitting course with trans-mural inflammation of potentially any section of the …

Objective. To assess the efficacy and safety of the fully human recombinant monoclonal anti-
TNF antibody adalimumab in routine clinical practice, including comparison of patients with …

TNF-α is a potent inducer of the inflammatory response, a key regulator of innate immunity
and plays an important role in the regulation of Th1 immune responses against intracellular …

Tumor necrosis factor (TNF) is a proinflammatory cytokine that is involved with normal
inflammatory and immune responses and with the pathogenesis of chronic inflammatory …