Asparagine is a non-essential amino acid crucial for protein biosynthesis and function, and
therefore cell maintenance and growth. Furthermore, this amino acid has an important role …

Amino acids play central roles in cancer progression beyond their function as building
blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been …

Nutrient bioavailability in the tumor microenvironment plays a pivotal role in tumor
proliferation and metastasis. Among these nutrients, glutamine is a key substance that …

Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors.
Asparagine is an amino acid that is synthesized by normal cells. However, some cancer …

The chemotherapeutic enzyme asparaginase depletes systemic asparagine to kill cancers;
however, its efficacy thus far is limited to a subset of leukemias. Hinze and colleagues …

Asparagine, an important amino acid in mammals, is produced in several organs and is
widely used for the production of other nutrients such as glucose, proteins, lipids, and …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids
that can be produced in our body. However, they are essential for the growth of highly …

Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in
acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the …

Reprogramming of energy metabolism is regarded as one of the hallmarks of cancer; in
particular, oncogenic RAS has been shown to be a critical regulator of cancer metabolism …