Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

CE Murry, G Keller - Cell, 2008 - cell.com
The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

In vitro differentiation of embryonic stem cells

GM Keller - Current opinion in cell biology, 1995 - Elsevier
Under appropriate conditions in culture, embryonic stem cells with differentiate and form
embryoid bodies that have been shown to contain cells of the hematopoietic, endothelial …

Embryonic stem cell differentiation: emergence of a new era in biology and medicine

G Keller - Genes & development, 2005 - genesdev.cshlp.org
The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Derivation and spontaneous differentiation of human embryonic stem cells

M Amit, J Itskovitz‐Eldor - Journal of anatomy, 2002 - Wiley Online Library
Embryonic stem (ES) cells are unique cells derived from the inner cell mass of the
mammalian blastocyst. These cells are immortal and pluripotent, retain their developmental …

Embryonic stem cells: prospects for developmental biology and cell therapy

AM Wobus, KR Boheler - Physiological reviews, 2005 - journals.physiology.org
Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Embryonic stem cells: understanding their history, cell biology and signalling

R Friel, S Van Der Sar, PJ Mee - Advanced drug delivery reviews, 2005 - Elsevier
Embryonic stem cells offer enormous potential as a source of a variety of differentiated cells
for cell therapy, drug discovery and toxicology screening. With the creation of human …

Human embryonic stem cells: prospects for development

MF Pera, AO Trounson - 2004 - journals.biologists.com
It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental
model for studying early development in our species, and, conversely, that studies of …

Potential of embryonic stem cells

AM Wobus - Molecular aspects of medicine, 2001 - Elsevier
Embryonic stem (ES) cells are pluripotent cell lines established from undifferentiated
embryonic cells characterized by nearly unlimited self-renewal and differentiation capacity …

[PDF][PDF] Embryonic stem cells

A Smith - COLD SPRING HARBOR MONOGRAPH SERIES, 2001 - s2.bitdl.ir
Embryonic stem (ES) cells are pluripotent stem cell lines derived directly from early mouse
embryos without use of immortalizing or transforming agents. They can be propagated as …

Pharmaceutical applications of embryonic stem cells

CW Pouton, JM Haynes - Advanced Drug Delivery Reviews, 2005 - Elsevier
Embryonic stem cells (ESCs) will become a source of all adult differentiated cells once
reliable protocols for directed differentiation have been established. This resource will …