Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

Purpose: The transcription factor nuclear factor-κB (NF-κB) promotes the production of
angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis …

Inflammation is involved in regulation of cellular events in prostate carcinogenesis through
control of the tumour micro‐environment. A variety of bone marrow‐derived cells, including …

Prostate carcinoma (PCa) displays a wide variety of genetic alterations, versatile expression
profiles as well as cell surface markers. Despite this heterogeneity, a common treatment for …

Rel/NF-ΚB transcription factors are key regulators of genes implicated in inflammatory and
immune activation, cell growth and protection from apoptosis. Constitutive activation of NF …

Background: Cell line models suggest that activation of NFκB is associated with progression
of prostate cancer. This pathway may be a therapeutic target if these observations translate …

Prostate cancers that progress during androgen-deprivation therapy often overexpress the
androgen receptor (AR) and depend on AR signaling for growth. In most cases, increased …

Typically, the initial response of a prostate cancer patient to androgen ablation therapy is
regression of the disease. However, the tumor will progress to an “androgen-independent” …

The NF‐κB family of transcription factors has been shown to be constitutively activated in
various human malignancies, including leukemias, lymphomas, and a number of solid …

Increased androgen receptor (AR) levels are associated with prostate cancer progression to
androgen independence and therapy resistance. Evidence has suggested that chronic …