Bulk RNA sequencing of a tissue captures the gene expression profile from all cell types
combined. Single-cell RNA sequencing identifies discrete cell-signatures based on …

The cornea is the clear window that lets light into the eye. It is composed of five layers:
epithelium, Bowman's layer, stroma, Descemet's membrane and endothelium. The …

In order to identify reliable markers of corneal epithelial stem cells, we employed an
inducible transgenic “pulse-chase” murine model (K5Tta× TRE-H2BGFP) to localize, purify …

Purpose This study aimed to uncover novel cell types in heterogenous basal limbus of
human cornea for identifying LSC at single cell resolution. Methods Single cells of human …

Purpose The corneal limbus maintains the homeostasis, immune and angiogenic privilege
of cornea. This study aimed to depict the landscape of human limbal tissues by single-cell …

Purpose Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to
generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell …

It has been suggested that the isolation of scalable populations of limbal stem cells may lead
to radical changes in ocular therapy. In particular, the derivation and transplantation of …

The corneal endothelium maintains corneal transparency; consequently, damage to this
endothelium by a number of pathological conditions results in severe vision loss. Publicly …

Purpose: Defects in neural crest development are a major contributing factor in corneal
dysgenesis, but little is known about the genetic landscape during corneal development …

Corneal endothelial cells (CECs) are terminally differentiated cells, specialized in regulating
corneal hydration and transparency. They are highly polarized flat cells that separate the …