Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model
In peripheral arterial disease (PAD), the degree of endogenous capacity to modulate
revascularization of limb muscle is central to the management of leg ischemia. To …
revascularization of limb muscle is central to the management of leg ischemia. To …
Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …
morbidity, along with the advent of powerful computational resources, have fostered an …
A fully coupled computational fluid dynamics–agent-based model of atherosclerotic plaque development: multiscale modeling framework and parameter sensitivity …
Abstract Background Peripheral Artery Disease (PAD) is an atherosclerotic disorder that
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
Multiscale computational modeling in vascular biology: from molecular mechanisms to tissue-level structure and function
Blood vessels exhibit a remarkable ability to adapt in response to sustained alterations in
hemodynamic loads and diverse disease processes. Although such adaptations typically …
hemodynamic loads and diverse disease processes. Although such adaptations typically …
[HTML][HTML] A multiscale computational framework to understand vascular adaptation
The failure rate for vascular interventions (vein bypass grafting, arterial angioplasty/stenting)
remains unacceptably high. Over the past two decades, researchers have applied a wide …
remains unacceptably high. Over the past two decades, researchers have applied a wide …
A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation
Peripheral arterial occlusive disease is a chronic pathology affecting at least 8–12 million
people in the USA, typically treated with a vein graft bypass or through the deployment of a …
people in the USA, typically treated with a vein graft bypass or through the deployment of a …
Systems biology of the microvasculature
LE Clegg, F Mac Gabhann - Integrative Biology, 2015 - academic.oup.com
The vascular network carries blood throughout the body, delivering oxygen to tissues and
providing a pathway for communication between distant organs. The network is hierarchical …
providing a pathway for communication between distant organs. The network is hierarchical …
Cell signaling model for arterial mechanobiology
L Irons, JD Humphrey - PLoS computational biology, 2020 - journals.plos.org
Arterial growth and remodeling at the tissue level is driven by mechanobiological processes
at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote …
at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote …
Regenerated microvascular networks in ischemic skeletal muscle
H Yin, JM Arpino, JJ Lee, JG Pickering - Frontiers in Physiology, 2021 - frontiersin.org
Skeletal muscle is the largest organ in humans. The viability and performance of this
metabolically demanding organ are exquisitely dependent on the integrity of its …
metabolically demanding organ are exquisitely dependent on the integrity of its …
Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling
The vascular system, essential for human physiology, is vital for transporting nutrients,
oxygen, and waste. Since vascular structures are involved in various disease pathogeneses …
oxygen, and waste. Since vascular structures are involved in various disease pathogeneses …