Several studies have shown that promoters of protein-coding genes are origins of pervasive
non-coding RNA transcription and can initiate transcription in both directions. However, only …

Mammalian genomes are extensively transcribed outside the borders of protein-coding
genes. Genome-wide studies recently demonstrated that cis-regulatory genomic elements …

Transcription is the focus of much cutting-edge research, as befits its essential place in
biology. The established link between defects in gene transcription and many human …

Many active eukaryotic gene promoters exhibit divergent noncoding transcription, but the
mechanisms restricting expression of these transcripts are not well understood. Here, we …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

In metazoans, thousands of protein-coding genes must be differentially expressed in specific
cell types, during development, and in response to a wide variety of extracellular signals …

The sequencing of the human genome led to many insights into gene organization and
structure. One interesting observation was the high frequency of bidirectional promoters …

Increasing numbers of transcripts have been reported to transmit both protein-coding and
regulatory information. Apart from challenging our conception of the gene, this observation …

Background Bidirectional promoters lie between adjacent genes, which are transcribed from
opposite strands of DNA. The functional mechanisms underlying the activation of …

The mammalian genome is extensively transcribed, a large fraction of which is divergent
transcription from promoters and enhancers that is tightly coupled with active gene …