Alzheimer's disease (AD) is a multifactorial neurological disorder among elderly people and
combinatorial factors such as genetic, lifestyle, and environmental are involved in onset and …

Alzheimer's disease is a neurological disorder, which is the most common form of dementia
affecting mostly elderly people. The number of patients is still rapidly increasing which …

Alzheimer's disease (AD) is a neurodegenerative disorder, which is complex and
progressive; it has not only threatened the health of elderly people, but also burdened the …

Background: The design of multifunctional agents represents one of the most active
research field in medicinal chemistry. In particular, tacrine, a well known …

Alzheimer's disease (AD) is the most common cause of dementia, clinically characterized by
loss of memory and progressive deficits in different cognitive domains. An emerging disease …

To date, the pharmacotherapy of Alzheimer's disease (AD) has relied on
acetylcholinesterase (AChE) inhibitors (AChEIs) and, more recently, an N-methyl-D …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed
based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in …

Alzheimer's disease (AD) is a multifactorial disorder with several target proteins contributing
to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that …