A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance
Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …
MicroRNAs and potential targets in osteosarcoma
VB Sampson, S Yoo, A Kumar, NS Vetter… - Frontiers in …, 2015 - frontiersin.org
Osteosarcoma is the most common bone cancer in children and young adults. Surgery and
multi-agent chemotherapy are the standard treatment regimens for this disease. New …
multi-agent chemotherapy are the standard treatment regimens for this disease. New …
MicroRNA involvement in osteosarcoma
E Kobayashi, FJ Hornicek, Z Duan - Sarcoma, 2012 - Wiley Online Library
Osteosarcoma (OS) is the most common primary malignant bone tumor, usually arising in
the long bones of adolescents and young adults. While our knowledge of the molecular …
the long bones of adolescents and young adults. While our knowledge of the molecular …
MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of
osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 …
osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 …
MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects
J Miao, S Wu, Z Peng, M Tania, C Zhang - Tumor Biology, 2013 - Springer
MicroRNAs (miRNAs) are small RNA molecules, which can interfere with the expression of
several genes and act as gene regulator. miRNAs have been proved as a successful …
several genes and act as gene regulator. miRNAs have been proved as a successful …
The role of miRNA in the diagnosis, prognosis, and treatment of osteosarcoma
J Wang, S Liu, J Shi, J Li, S Wang, H Liu… - Cancer biotherapy & …, 2019 - liebertpub.com
Osteosarcoma (OS) is one of the most common malignant tumors derived from
mesenchymal tissue and is highly invasive, mainly in children and adolescents. Treatment of …
mesenchymal tissue and is highly invasive, mainly in children and adolescents. Treatment of …
Involvement and clinical aspects of microRNA in osteosarcoma
RM Ram Kumar, A Boro, B Fuchs - International journal of molecular …, 2016 - mdpi.com
Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents,
but its pathogenesis has been difficult to establish because of its well-known heterogeneous …
but its pathogenesis has been difficult to establish because of its well-known heterogeneous …
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma
Osteosarcoma is one of the most prevalent primary bone tumors with a high metastatic and
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …
Modulation of the osteosarcoma expression phenotype by microRNAs
HM Namløs, LA Meza-Zepeda, T Barøy, IHG Østensen… - PloS one, 2012 - journals.plos.org
Background Osteosarcomas are the most common primary malignant tumors of bone and
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …
show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of …
Analysis of miRNA-gene expression-genomic profiles reveals complex mechanisms of microRNA deregulation in osteosarcoma
G Maire, JW Martin, M Yoshimoto, S Chilton-MacNeill… - Cancer genetics, 2011 - Elsevier
Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic
instability and recurrent DNA deletions and amplifications. This study assesses whether …
instability and recurrent DNA deletions and amplifications. This study assesses whether …