The metabolic investigation of the human population is becoming increasingly important in
the study of health and disease. The phenotypic variation can be investigated through the …

Metabolomics studies aim at a better understanding of biochemical processes by studying
relations between metabolites and between metabolites and other types of information (eg …

High-throughput metabolomics investigations, when conducted in large human cohorts,
represent a potentially powerful tool for elucidating the biochemical diversity underlying …

Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

Highlights•Metabolomics enables rapid measurements at 10–100 times higher throughput
than proteomics.•The achievable throughput opens entirely new scientific and medical …

Untargeted metabolomics is an analytical approach with numerous applications serving as
an effective metabolic phenotyping platform to characterize small molecules within a …

In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

With the increasing production of metabolomic data there is an awareness of a need for a
standardised description of this data to aid assessment, exchange, storage and curation of …