Energy metabolism plays an important role in cell and tissue ability to effectively function,
maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal …

Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …

Abstract Purpose of Review Osteoblasts are responsible for bone matrix production during
bone development and homeostasis. Much is known about the transcriptional regulation …

Biological processes utilize energy and therefore must be prioritized based on fuel
availability. Bone is no exception to this, and the benefit of remodeling when necessary …

The rising incidence of metabolic diseases worldwide has prompted renewed interest in the
study of intermediary metabolism and cellular bioenergetics. The application of modern …

Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

Abstract Purpose of Review In this review, we provide a recent update on bioenergetic
pathways in osteocytes and identify potential future areas of research interest. Studies have …

Osteoblasts primarily mediate bone formation, maintain bone structure, and regulate bone
mineralization, which plays an important role in bone remodeling. In the past decades, the …

Osteogenic differentiation, the process by which bone marrow mesenchymal stem/stromal
(aka skeletal stem) cells and osteoprogenitors form osteoblasts, is a critical event for bone …

The role of energy metabolism in bone cells is an active field of investigation. Bone cells are
metabolically very active and require high levels of energy in the form of adenosine …