SHED‐exos promote saliva secretion by suppressing p‐ERK1/2‐mediated apoptosis in glandular cells
WX Chu, C Ding, ZH Du, P Wei, YX Wang, XJ Ge… - Oral …, 2023 - Wiley Online Library
Objectives Confirm that stem cells from human exfoliated deciduous teeth‐derived
exosomes (SHED‐exos) can limit inflammation‐triggered epithelial cell apoptosis and …
exosomes (SHED‐exos) can limit inflammation‐triggered epithelial cell apoptosis and …
[HTML][HTML] Dental pulp stem cell-derived exosomes revitalize salivary gland epithelial cell function in NOD mice via the GPER-mediated cAMP/PKA/CREB signaling …
S Hu, B Chen, J Zhou, F Liu, T Mao, JL Pathak… - Journal of Translational …, 2023 - Springer
Background Restoration of salivary gland function in Sjogren's syndrome (SS) is still a
challenge. Dental pulp stem cells (DPSCs) derived exosomes had shown anti-inflammatory …
challenge. Dental pulp stem cells (DPSCs) derived exosomes had shown anti-inflammatory …
SHED-derived exosomes ameliorate hyposalivation caused by Sjögren's syndrome via Akt/GSK-3β/Slug-mediated ZO-1 expression
Z Du, P Wei, N Jiang, L Wu, C Ding, G Yu - Chinese Medical Journal, 2023 - mednexus.org
Background: Sjögren's syndrome (SS) is an autoimmune disorder characterized by sicca
syndrome and/or systemic manifestations. The treatment is still challenging. This study …
syndrome and/or systemic manifestations. The treatment is still challenging. This study …
[HTML][HTML] Translational and clinical applications of dental stem cell-derived exosomes
Z Mai, H Chen, Y Ye, Z Hu, W Sun, L Cui… - Frontiers in genetics, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration
due to their featured properties of self-renewal and multipotency. However, a growing body …
due to their featured properties of self-renewal and multipotency. However, a growing body …
Efficacy of mesenchymal stem cells from human exfoliated deciduous teeth and their derivatives in inflammatory diseases therapy
J Su, X Ge, N Jiang, Z Zhang… - Current Stem Cell …, 2022 - ingentaconnect.com
Mesenchymal stem cells derived from postnatal orofacial tissues can be readily isolated and
possess diverse origins, for example, from surgically removed teeth or gingiva. These cells …
possess diverse origins, for example, from surgically removed teeth or gingiva. These cells …
[HTML][HTML] SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy
Y Xie, L Yu, Z Cheng, Y Peng, Z Cao, B Chen… - Journal of …, 2022 - Springer
High-quality cutaneous wound healing is associated with rapid wound closure and a
comfortable healing process. Currently, exosomes derived from mesenchymal stem cells …
comfortable healing process. Currently, exosomes derived from mesenchymal stem cells …
Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis
J Wei, Y Song, Z Du, F Yu, Y Zhang, N Jiang… - Journal of molecular …, 2020 - Springer
Cell-free based therapy is an effective strategy in regenerative medicine as it avoids
controversial issues, such as immunomodulation and stability. Recently, exosomes have …
controversial issues, such as immunomodulation and stability. Recently, exosomes have …
[HTML][HTML] Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246
P Liu, Q Zhang, J Mi, S Wang, Q Xu, D Zhuang… - Stem Cell Research & …, 2022 - Springer
Background Anti-angiogenic therapy has been shown to be a promising strategy for anti-
tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by …
tumor treatment. Increasing evidence indicates that tumor angiogenesis is affected by …
Secretome of stem cells from human exfoliated deciduous teeth (SHED) and its extracellular vesicles improves keratinocytes migration, viability, and attenuation of …
Therapies for wound healing using the secretome and extracellular vesicles (EVs) of
mesenchymal stem/stromal cells have been shown to be successful in preclinical studies …
mesenchymal stem/stromal cells have been shown to be successful in preclinical studies …
[HTML][HTML] Exosomes from oral tissue stem cells: Biological effects and applications
Q Shi, N Huo, X Wang, S Yang, J Wang, T Zhang - Cell & Bioscience, 2020 - Springer
As natural nanoparticles, exosomes are a type of extracellular vesicles that are enclosed by
a lipid bilayer and contain various cargos, including miRNA, mRNA, DNA and proteins …
a lipid bilayer and contain various cargos, including miRNA, mRNA, DNA and proteins …