Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems
R Bajracharya, JG Song, BR Patil, SH Lee, HM Noh… - Drug Delivery, 2022 - Taylor & Francis
Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …
Advances in receptor‐mediated, tumor‐targeted drug delivery
Receptor‐mediated drug delivery presents an opportunity to enhance therapeutic efficiency
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
Small molecules for active targeting in cancer
For the purpose of this review, active targeting in cancer research encompasses strategies
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …
wherein a ligand for a cell surface receptor expressed on tumor cells is used to deliver a …
Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach
A Rana, S Bhatnagar - Bioorganic chemistry, 2021 - Elsevier
Targeted delivery combined with controlled release of drugs has a crucial role in future of
personalized medicine. The majority of cancer drugs are intended to interfere with one or …
personalized medicine. The majority of cancer drugs are intended to interfere with one or …
Ligand-targeted drug delivery
M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
Targeted anticancer therapy: overexpressed receptors and nanotechnology
Targeted delivery of anticancer drugs to cancer cells and tissues is a promising field due to
its potential to spare unaffected cells and tissues, but it has been a major challenge to …
its potential to spare unaffected cells and tissues, but it has been a major challenge to …
Nanoparticle-based drug delivery systems targeting cancer cell surfaces
L Hong, W Li, Y Li, S Yin - RSC advances, 2023 - pubs.rsc.org
Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …
Targeted drug delivery in cancer therapy
JK Vasir, V Labhasetwar - Technology in cancer research & …, 2005 - journals.sagepub.com
Chemotherapy has been the main modality of treatment for cancer patients; however, its
success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue …
success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue …
Ligand-based targeted therapy for cancer tissue
M Das, C Mohanty, SK Sahoo - Expert opinion on drug delivery, 2009 - Taylor & Francis
Background: Limited accessibility of drugs to the tumor tissues, the requirement of high
doses, intolerable cytotoxicity, the development of multiple drug resistance and non-specific …
doses, intolerable cytotoxicity, the development of multiple drug resistance and non-specific …
Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …