[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

[PDF][PDF] Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system

RA Santos, AJ Ferreira, T Verano-Braga, M Bader - J endocrinol, 2013 - academia.edu
Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Angiotensin-(1–7): beyond the cardio-renal actions

DG Passos-Silva, T Verano-Braga… - Clinical …, 2013 - portlandpress.com
It is well known that the RAS (renin–angiotensin system) plays a key role in the modulation
of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) …

ACE2, angiotensin-(1–7), and Mas: the other side of the coin

M Bader - Pflügers Archiv-European Journal of Physiology, 2013 - Springer
The renin–angiotensin system (RAS) has recently been extended by the addition of a novel
axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide …

ACE2 of the heart: from angiotensin I to angiotensin (1–7)

S Keidar, M Kaplan… - Cardiovascular …, 2007 - academic.oup.com
Abstract Angiotensin II (Ang II), a bioactive peptide of the renin–angiotensin system (RAAS),
plays an important role in the development of cardiovascular diseases (CVD) …

Recent advances in the angiotensin‐converting enzyme 2–angiotensin (1–7)–Mas axis

RAS Santos, AJ Ferreira… - Experimental …, 2008 - Wiley Online Library
In the past few years, the classical concept of the renin–angiotensin system (RAS) has
experienced substantial conceptual changes. The identification of: the renin/prorenin …

Angiotensin-(1–7) and the renin–angiotensin system

RAS Santos, AJ Ferreira - Current opinion in nephrology and …, 2007 - journals.lww.com
The previously unsuspected complexity of the renin–angiotensin system, unmasked by
novel findings, has revealed new possibilities for exploring its physiological and …

Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases

AJ Ferreira, RAS Santos, CN Bradford, AP Mecca… - …, 2010 - Am Heart Assoc
Despite the tremendous success obtained using the current pharmacotherapy, especially
angiotensin (Ang)-converting enzyme (ACE) inhibitors (ACEis) and Ang II receptor blockers …

[HTML][HTML] The renin-angiotensin system: going beyond the classical paradigms

RAS Santos, GY Oudit… - American Journal …, 2019 - journals.physiology.org
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

P Xu, S Sriramula… - American Journal of …, 2011 - journals.physiology.org
The last decade has seen the discovery of several new components of the renin-angiotensin
system (RAS). Among them, angiotensin converting enzyme-2 (ACE2) and the Mas receptor …