Advances in heterocycles as DNA intercalating cancer drugs
A Das, BK Banik - Physical Sciences Reviews, 2023 - degruyter.com
The insertion of a molecule between the bases of DNA is known as intercalation. A molecule
is able to interact with DNA in different ways. DNA intercalators are generally aromatic …
is able to interact with DNA in different ways. DNA intercalators are generally aromatic …
Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling
A Rescifina, C Zagni, MG Varrica, V Pistarà… - European journal of …, 2014 - Elsevier
The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …
DNA intercalators as anticancer agents
Cancer is one of the most prevailing disease conditions, which occurs due to uncontrolled
cell division either due to natural mutation to the genes or due to changes induced by …
cell division either due to natural mutation to the genes or due to changes induced by …
A comprehensive review on fused heterocyclic as DNA intercalators: Promising anticancer agents
Since the discovery of DNA intercalating agents (by Lerman, 1961), a growing number of
organic, inorganic, and metallic compounds have been developed to treat life-threatening …
organic, inorganic, and metallic compounds have been developed to treat life-threatening …
Natural DNA intercalators as promising therapeutics for cancer and infectious diseases
M Godzieba, S Ciesielski - Current cancer drug targets, 2020 - ingentaconnect.com
Cancer and infectious diseases are one of the greatest challenges of modern medicine. An
unhealthy lifestyle, the improper use of drugs, or their abuse are conducive to the increase of …
unhealthy lifestyle, the improper use of drugs, or their abuse are conducive to the increase of …
Intercalative drug binding to DNA
AHJ Wang - Current Opinion in Structural Biology, 1992 - Elsevier
Intercalator drugs are important in the treatment of cancers. The molecular interactions
between them and DNA have been studied by X-ray diffraction and NMR. Some important …
between them and DNA have been studied by X-ray diffraction and NMR. Some important …
[PDF][PDF] DNA intercalators and using them as anticancer drugs
MK Goftar, NM Kor, ZM Kor - Int. J. Adv. Biol. Biomed. Res, 2014 - researchgate.net
Many anticancer drugs in clinical use interact with DNA through intercalation, which is
process that starts with the transfer of the intercalating molecule from an aqueous …
process that starts with the transfer of the intercalating molecule from an aqueous …
Considerations concerning design and mechanism of action of a new class of anticancer dual DNA intercalators
Cancer is one of the most serious and merciless health problems of the mankind, about
seven million people dying of cancer every year. Two of the most important and promising …
seven million people dying of cancer every year. Two of the most important and promising …
[HTML][HTML] Recent developments in the chemistry of deoxyribonucleic acid (DNA) intercalators: principles, design, synthesis, applications and trends
In the present overview, we describe the bases of intercalation of small molecules (cationic
and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure …
and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure …
DNA intercalators in cancer therapy: organic and inorganic drugs and their spectroscopic tools of analysis
NJ Wheate, CR Brodie, JG Collins… - Mini reviews in …, 2007 - ingentaconnect.com
Since the discovery of the DNA intercalation process by Lerman in 1961 thousands of
organic, inorganic octahedral (particularly ruthenium (II) and rhodium (III)) and square …
organic, inorganic octahedral (particularly ruthenium (II) and rhodium (III)) and square …