Nonenzymatic nucleic acid amplification techniques (eg the hybridization chain reaction,
HCR) have shown promising potential for amplified detection of biomarkers. However, the …

Biomolecular self-assembly has spurred substantial research efforts for the development of
low-cost point-of-care diagnostics. Herein, we introduce an isothermal enzyme-free …

Nucleic acid circuits have shown promising potential for amplified detection of biomarkers
with interest in biologically important engineering applications. In this work, by properly …

Hybridization chain reaction (HCR) can be divided into two categories: linear HCR and
nonlinear HCR. In traditional linear HCR, the relatively slow kinetics and less sufficient …

With the continuous development of DNA nanotechnology, various spatial DNA structures
and assembly techniques emerge. Hybridization chain reaction (HCR) is a typical example …

Herein, an innovative fluorescent sensor was courageously empoldered for precise and
ultrasensitive detection and imaging of target miRNA-21 through the agency of a dextrous …

Three-dimensional (3D) DNA scaffolds with well-defined structure and high controllability
hold promising potentials for biosensing and drug delivery. However, most of 3D DNA …

Engineering of multivariate biosensing and imaging platforms involved in disease plays a
vital role in effectively discerning cancer cells from normal cells and facilitating reliable …

Hybridization chain reaction (HCR) is a simple isothermal enzyme-free process with the
advantages of high simplicity and versatility. Generally, initiator single-stranded DNA is …

Sensitive detection of cancer cells plays a critically important role in the early detection of
cancer and cancer metastasis. However, because circulating tumor cells are extremely rare …