[HTML][HTML] Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens

JC Hyun, ES Kavvas, JM Monk… - PLoS computational …, 2020 - journals.plos.org
The evolution of antimicrobial resistance (AMR) poses a persistent threat to global public
health. Sequencing efforts have already yielded genome sequences for thousands of …

A genomic data resource for predicting antimicrobial resistance from laboratory-derived antimicrobial susceptibility phenotypes

M VanOeffelen, M Nguyen, D Aytan-Aktug… - Briefings in …, 2021 - academic.oup.com
Antimicrobial resistance (AMR) is a major global health threat that affects millions of people
each year. Funding agencies worldwide and the global research community have expended …

Prediction of antimicrobial resistance based on whole-genome sequencing and machine learning

Y Ren, T Chakraborty, S Doijad, L Falgenhauer… - …, 2022 - academic.oup.com
Motivation Antimicrobial resistance (AMR) is one of the biggest global problems threatening
human and animal health. Rapid and accurate AMR diagnostic methods are thus very …

Assessing computational predictions of antimicrobial resistance phenotypes from microbial genomes

K Hu, F Meyer, ZL Deng, E Asgari, TH Kuo… - Briefings in …, 2024 - academic.oup.com
The advent of rapid whole-genome sequencing has created new opportunities for
computational prediction of antimicrobial resistance (AMR) phenotypes from genomic data …

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains

J Sunuwar, RK Azad - Briefings in Bioinformatics, 2021 - academic.oup.com
Recently, the frequency of observing bacterial strains without known genetic components
underlying phenotypic resistance to antibiotics has increased. There are several strains of …

Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes

J Jeukens, I Kukavica-Ibrulj… - FEMS microbiology …, 2017 - academic.oup.com
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The
accessibility of microbial whole-genome sequencing offers an invaluable opportunity for …

Predicting antimicrobial resistance and associated genomic features from whole-genome sequencing

JM Monk - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Thanks to the genomics revolution, thousands of strain-specific whole-genome sequences
are now accessible for a wide range of pathogenic bacteria. This availability enables big …

[HTML][HTML] Enhancing predictions of antimicrobial resistance of pathogens by expanding the potential resistance gene repertoire using a pan-genome-based feature …

MR Yang, YW Wu - BMC bioinformatics, 2022 - Springer
Background Predicting which pathogens might exhibit antimicrobial resistance (AMR) based
on genomics data is one of the promising ways to swiftly and precisely identify AMR …

AMR-meta: a k-mer and metafeature approach to classify antimicrobial resistance from high-throughput short-read metagenomics data

S Marini, M Oliva, IB Slizovskiy, RA Das… - …, 2022 - academic.oup.com
Background Antimicrobial resistance (AMR) is a global health concern. High-throughput
metagenomic sequencing of microbial samples enables profiling of AMR genes through …

[HTML][HTML] Exploiting genomics to mitigate the public health impact of antimicrobial resistance

C Waddington, ME Carey, CJ Boinett, E Higginson… - Genome medicine, 2022 - Springer
Antimicrobial resistance (AMR) is a major global public health threat, which has been largely
driven by the excessive use of antimicrobials. Control measures are urgently needed to slow …