Background Renal perfusion status remains poorly studied at the bedside during septic
shock. We sought to measure cortical renal perfusion in patients with septic shock during …

Introduction Septic renal failure is often seen in the intensive care unit but its pathogenesis is
only partly understood. This study, performed in a normotensive rat model of endotoxemia …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …

Introduction To assess changes in renal blood flow (RBF) in human and experimental
sepsis, and to identify determinants of RBF. Method Using specific search terms we …

Methods In eight anesthetized, mechanically ventilated and instrumented pigs, fecal
peritonitis was induced by inoculating autologous feces. Six sham-operated animals served …

Introduction Fluid administration is a first-line therapy for acute kidney injury associated with
circulatory failure. Although aimed at increasing renal perfusion in these patients, this …

Abstract Introduction In ICUs, both fluid overload and oliguria are common complications
associated with increased mortality among critically ill patients, particularly in acute kidney …

Introduction Septic shock is characterized by altered tissue perfusion associated with
persistent arterial hypotension. Vasopressor therapy is generally required to restore organ …

Introduction During critical illness, oliguria is often used as a biomarker of acute kidney
injury (AKI). However, its relationship with the subsequent development of AKI has not been …

Introduction Serum creatinine concentration (sCr) is the marker used for diagnosing and
staging acute kidney injury (AKI) in the RIFLE and AKIN classification systems, but is …