Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

What are the effects of our environment on human development and the next generation?
Numerous studies have provided ample evidence that a healthy environment and lifestyle of …

The use of non-human animals in research is a longstanding practice to help us understand
and improve human biology and health. Animal models allow researchers, for example, to …

Throughout our lives, epigenetic processes shape our development and enable us to adapt
to a constantly changing environment. Identifying and understanding environmentally …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

Traditional studies on the combined effects of genetics and the environment on individual
variation in disease susceptibility primarily focus on single nucleotide polymorphisms that …

Genetic studies traditionally focus on DNA as the molecule that passes information on from
parents to their offspring. Changes in the DNA code alter heritable information and can more …

Epigenetics investigates heritable changes in gene expression that occur without changes
in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone …

Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …

Epidemiological studies have shown that the environment experienced in early life can
'programme'susceptibility to later disease. Furthermore, there is increasing evidence that …