Tobacco-specific nitrosamines: A literature review

E Konstantinou, F Fotopoulou, A Drosos… - Food and chemical …, 2018 - Elsevier
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific
nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period …

Tobacco-specific nitrosamines in the tobacco and mainstream smoke of US commercial cigarettes

SH Edwards, LM Rossiter, KM Taylor… - Chemical research in …, 2017 - ACS Publications
Tobacco-specific nitrosamines (TSNAs) are N-nitroso-derivatives of pyridine-alkaloids (eg,
nicotine) present in tobacco and cigarette smoke. Two TSNAs, N′-nitrosonornicotine (NNN) …

Tobacco-specific nitrosamines in new tobacco products

I Stepanov, J Jensen, D Hatsukami… - Nicotine & Tobacco …, 2006 - academic.oup.com
New tobacco products, designed to attract consumers who are concerned about the health
effects of tobacco, have been appearing on the market. Objective evaluation of these …

Tobacco‐specific N‐nitrosamines and ARECA‐derived N‐nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans

D Hoffmann, KD Brunnemann… - Journal of Toxicology …, 1994 - Taylor & Francis
Nicotine and the minor tobacco alkaloids give rise to tobacco‐specific N‐nitrosamines
(TSNA) during tobacco processing and during smoking. Chemical‐analytical studies led to …

Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry

I Stepanov, A Knezevich, L Zhang… - Tobacco …, 2012 - tobaccocontrol.bmj.com
Background Modification of tobacco curing methods and other changes in cigarette
manufacturing techniques could substantially reduce the levels of tobacco-specific …

It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco

SS Hecht - Cancer Prevention Research, 2014 - AACR
Abstract The Family Smoking Prevention and Tobacco Control Act gives the US Food and
Drug Administration power to regulate tobacco products. This commentary calls for …

Metabolic activation and detoxification of tobacco-specific nitrosamines–a model for cancer prevention strategies

SS Hecht - Drug metabolism reviews, 1994 - Taylor & Francis
In a “landmark interview” on the subject of the Millers' seminal paper on the presence of
bound aminoazo dyes in the livers of rats fed p-dimethylaminoazobenzene, James A. Miller …

N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke

AR Tricker, C Ditrich, R Preussmann - Carcinogenesis, 1991 - academic.oup.com
The tobacco and mainstream smoke of 20 commercial brands of filter and non-filter
cigarettes were analysed for N-nitroso compounds. The concentrations of N …

Preformed tobacco-specific nitrosamines in tobacco—role of nitrate and influence of tobacco type

F Sophia, B Spiegelhalder, R Preussmann - Carcinogenesis, 1989 - academic.oup.com
Fifty-five types of con cigarettes on the open market in the FRG and several samples of pure
tobacco types were analyzed for preformed tobacco-specific nitrosamines (TSNA) and …

Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis

D Hoffmann, A Rivenson, FL Chung… - Critical reviews in …, 1991 - Taylor & Francis
Both smoking and chewing of tobacco deliver chemicals that affect physiological and
behavioral activity. These chemicals induce a dependency on tobacco which has fostered a …