[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent

SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Glucagon and glucagon-like peptide-1 as novel anti-inflammatory and immunomodulatory compounds

DBR Insuela, VF Carvalho - European journal of pharmacology, 2017 - Elsevier
Glucagon and glucagon-like peptide-1 (GLP-1) are polypeptide hormones that are produced
by pancreatic α-cells and the intestine, respectively, whose main function is to control …

[HTML][HTML] GLP-1 receptor agonist as a modulator of innate immunity

J Chen, A Mei, Y Wei, C Li, H Qian, X Min… - Frontiers in …, 2022 - frontiersin.org
Glucagon-like peptide-1 (GLP-1) is a 30-amino acid hormone secreted by L cells in the
distal ileum, colon, and pancreatic α cells, which participates in blood sugar regulation by …

GLP-1 secretion is increased by inflammatory stimuli in an IL-6–dependent manner, leading to hyperinsulinemia and blood glucose lowering

F Kahles, C Meyer, J Möllmann, S Diebold… - Diabetes, 2014 - Am Diabetes Assoc
Hypoglycemia and hyperglycemia are both predictors for adverse outcome in critically ill
patients. Hyperinsulinemia is induced by inflammatory stimuli as a relevant mechanism for …

Glucagon-like peptide-1 and glucagon-like peptide-2

LL Baggio, DJ Drucker - Best Practice & Research Clinical Endocrinology & …, 2004 - Elsevier
The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2
(GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 …

Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system

PL Brubaker, DJ Drucker - Endocrinology, 2004 - academic.oup.com
Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are …

Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications

SH Alharbi - Therapeutic Advances in Endocrinology and …, 2024 - journals.sagepub.com
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising
therapeutic agents with potent anti-inflammatory properties and diverse clinical implications …

Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration

N El-Jamal, E Erdual, M Neunlist… - American Journal …, 2014 - journals.physiology.org
The glucagon-like peptide 2 (GLP-2) is an intestinotrophic hormone with growth promoting
and anti-inflammatory actions. However, the full biological functions of GLP-2 and the …

Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2

CPA Ivory, LE Wallace… - American Journal of …, 2008 - journals.physiology.org
Glucagon-like peptide 2 (GLP-2) is an important intestinal growth factor with anti-
inflammatory activity. We hypothesized that GLP-2 decreases mucosal inflammation and the …

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation

CK Wong, BA McLean, LL Baggio, JA Koehler… - Cell Metabolism, 2024 - cell.com
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects
relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell …