We investigated the genotype-dependent therapeutic potential of targeting the
phosphoinositide 3-kinase (PI3K)/Akt pathway for thyroid cancer. Proliferation of TPC1 …

Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Abstract Context: The phosphoinositide 3-kinase (PI3K)/Akt pathway is widely postulated to
be an effective therapeutic target in thyroid cancer. Objective: The aim of the study was to …

Purpose: To investigate the overall occurrence and relationship of genetic alterations in the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway in thyroid tumors and explore the scope of …

Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-
kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and …

Purpose: In thyroid cancer clinical trials, agents targeting VEGF receptors (VEGFR) and
RET, among other kinases, have led to partial responses but few complete or durable …

Background: The mitogen-activated protein kinase (MAPK)/extracellular signal–regulated
kinase (ERK) pathway plays an important role in papillary and anaplastic thyroid cancer …

Purpose: We sought to determine whether phosphoinositide 3-kinase (PI3K) pathway
mutation or activation state and rapamycin-induced feedback loop activation of Akt is …

Context: Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and
their role in thyroid tumor pathogenesis in Chinese people remain undefined. Objective: The …

Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B-
signaling pathway has been associated with multiple human cancers, including thyroid …