Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …

Notch is needed for T-cell development and is a common oncogenic driver in T-cell acute
lymphoblastic leukemia. The protooncogene c-Myc (Myc) is a critical target of Notch in …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute
lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects …

The NOTCH1 signaling pathway directly links extracellular signals with transcriptional
responses in the cell nucleus and plays a critical role during T cell development and in the …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Cumulative evidence indicates that MYC, one of the major downstream effectors of
NOTCH1, is a critical component of T-cell acute lymphoblastic leukemia (T-ALL) …

Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal
translocations that involve NOTCH1, a gene encoding a transmembrane receptor that …

Notch signaling regulates myriad cellular functions by activating transcription, yet how Notch
selectively activates different transcriptional targets is poorly understood. The core Notch …

T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently
associated with chromosomal aberrations, but it was recently shown that most individuals …