In ancient DNA research, the degraded nature of the samples generally results in poor
yields of highly fragmented DNA; targeted DNA enrichment is thus required to maximize …

DNA capture coupled with next generation sequencing is highly suitable for the study of
ancient pathogens. Screening for pathogens can, however, be meticulous when assays are …

The majority of DNA recovered from ancient remains is derived from organisms that colonize
the remains post-mortem, such as soil microbes, or from contaminants, such as DNA from …

Due to the difficulties in deep sequencing, high-throughput sequencing of ancient DNA has
been limited to exceptionally well-preserved ancient materials. The primary factor is …

Ancient DNA analyses rely on the extraction of the tiny amounts of DNA remaining in
samples that are hundreds to tens of thousands of years old. Despite the critical role …

The DNA molecules that can be extracted from archaeological and palaeontological
remains are often degraded and massively contaminated with environmental microbial …

The use of hybridization capture has enabled a massive upscaling in sample sizes for
ancient DNA studies, allowing the analysis of hundreds of skeletal remains or sediments in …

It has been shown that highly fragmented DNA is most efficiently converted into DNA
libraries for sequencing if both strands of the DNA fragments are processed independently …

For many archaeological and paleontological samples, the relative content of endogenous
compared to contaminant DNA is low. In such cases, enriching sequencing libraries for …

High‐throughput sequencing has dramatically fostered ancient DNA research in recent
years. Shotgun sequencing, however, does not necessarily appear as the best‐suited …