[PDF][PDF] Power of inclusion: Enhancing polygenic prediction with admixed individuals
Y Tanigawa, M Kellis - The American Journal of Human Genetics, 2023 - cell.com
Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
High trait variability in optimal polygenic prediction strategy within multiple-ancestry cohorts
Polygenic scores (PGS) are individual-level measures that quantify the genetic contribution
to a given trait. PGS have predominantly been developed using European ancestry samples …
to a given trait. PGS have predominantly been developed using European ancestry samples …
[HTML][HTML] Optimal strategies for learning multi-ancestry polygenic scores vary across traits
Polygenic scores (PGSs) are individual-level measures that aggregate the genome-wide
genetic predisposition to a given trait. As PGS have predominantly been developed using …
genetic predisposition to a given trait. As PGS have predominantly been developed using …
[PDF][PDF] Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
The low portability of polygenic scores (PGSs) across global populations is a major concern
that must be addressed before PGSs can be used for everyone in the clinic. Indeed …
that must be addressed before PGSs can be used for everyone in the clinic. Indeed …
[PDF][PDF] Improving polygenic prediction with genetically inferred ancestry
Genome-wide association studies (GWASs) have demonstrated that most common diseases
have a strong genetic component from many genetic variants each with a small effect size …
have a strong genetic component from many genetic variants each with a small effect size …
[HTML][HTML] Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
Abstract Polygenic Scores (PSs) describe the genetic component of an individual's
quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs …
quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs …
High-resolution portability of 245 polygenic scores when derived and applied in the same cohort
The low portability of polygenic scores (PGS) across global populations is a major concern
that must be addressed before PGS can be used for everyone in the clinic. Indeed …
that must be addressed before PGS can be used for everyone in the clinic. Indeed …
Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
[HTML][HTML] Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods have
focused only on individuals with one primary continental ancestry, thus poorly …
focused only on individuals with one primary continental ancestry, thus poorly …