Macrophages play a prominent role in wound healing. In the early stages, they promote
inflammation and remove pathogens, wound debris, and cells that have apoptosed. Later in …

Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

Diabetic foot ulcers (DFUs) are one of the most costly and troublesome complications of
diabetes mellitus. The wound chronicity of DFUs remains the main challenge in the current …

Macrophage differentiation and polarization are essential players in the success of the
wound-healing process. Acute simple wounds progress from inflammation to proliferation …

Monocytes (Mo) and macrophages (Mϕ) play important roles in normal skin wound healing,
and dysregulation of wound Mo/Mϕ leads to impaired wound healing in diabetes. Although …

Purpose The failure in timely healing of wounds is a central feature in chronic wounds that
leads to physiological, psychological and economic burdens. Macrophages have been …

The healing of cutaneous wounds is dependent on the progression through distinct, yet
overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and …

Persistent inflammation is a major contributor to healing impairment in diabetic chronic
wounds. Paradoxically, diabetic wound environment during the acute phase of healing is …

Impaired wound healing is one of the severe complications of diabetes. Macrophages have
been shown to play a vital role in wound healing. In different wound environments …

Abstract Purpose of Review Diabetic foot ulcerations (DFU) affect 25% of patients with
diabetes mellitus during their lifetime and constitute a major health problem as they are often …