4‐Furfuryloxymethyl‐1, 2, 3‐triazol‐1‐yl‐acetohydrazide Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors: Synthesis, Characterization and …
H Şenol - ChemistrySelect, 2024 - Wiley Online Library
This study focused on the synthesis and evaluation of the biological activity of ten novel
acetohydrazide hybrid derivatives, having furfuryloxy‐1, 2, 3‐triazole ring. All the target …
acetohydrazide hybrid derivatives, having furfuryloxy‐1, 2, 3‐triazole ring. All the target …
Carboxylate‐and Sulfonate‐Containing Quinazolin‐4 (3H)‐one Rings: Synthesis, Characterization, and Carbonic Anhydrase I–II and Acetylcholinesterase Inhibition …
Quinazolines are a group of bioactive heterocyclic compounds with a wide range of
biological activities and have gained an important place in the design of active drugs with …
biological activities and have gained an important place in the design of active drugs with …
Synthesis and in vitro carbonic anhydrase and acetylcholinesterase inhibitory activities of novel hydrazide–hydrazone compounds containing 1,2,4-triazole ring
ED Dincel, ED Kuran, B Onarer, Y Fıstıkçı… - … , Sulfur, and Silicon …, 2024 - Taylor & Francis
Abstract In this work, 1, 2, 4-triazole derived hydrazide–hydrazones were synthesized with a
five-step synthesis pathway. The novel derivatives were characterized by various analytical …
five-step synthesis pathway. The novel derivatives were characterized by various analytical …
Design, synthesis, and molecular docking studies of benzimidazole‐1, 3, 4‐triazole hybrids as carbonic anhydrase I and II inhibitors
In this study, with an aim to develop novel heterocyclic hybrids as potent enzyme inhibitors,
we synthesized a series of 10 novel 2‐(4‐(4‐ethyl‐5‐(2‐(substitutedphenyl)‐2‐oxo …
we synthesized a series of 10 novel 2‐(4‐(4‐ethyl‐5‐(2‐(substitutedphenyl)‐2‐oxo …
Design and synthesis of pyrazole carboxamide derivatives as selective cholinesterase and carbonic anhydrase inhibitors: molecular docking and biological evaluation
The present study focused on the synthesis and characterization of novel pyrazole
carboxamide derivatives (SA1‐12). The inhibitory effect of the compounds on …
carboxamide derivatives (SA1‐12). The inhibitory effect of the compounds on …
Tail-approach based design and synthesis of Arylthiazolylhydrazono-1, 2, 3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II …
A library of twenty-two arylthiazolylhydrazono-1, 2, 3-triazoles incorporating sulfanilamide
and metanilamide moieties have been synthesized by utilizing tail-approach and …
and metanilamide moieties have been synthesized by utilizing tail-approach and …
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1, 2, 3-triazole chalcone hybrids
Sulfonamide is one of the most promising classes of classical carbonic anhydrase (CA, EC
4.2. 1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1 …
4.2. 1.1) inhibitors. A novel series of indolylchalcones incorporating benzenesulfonamide-1 …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo [2, 1-b][1, 3, 4] thiadiazoles as highly potent acetylcholinesterase and non …
Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
4-Functionalized 1, 3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII
M Ceruso, P Khloya, CT Supuran, PK Sharma - Bioorganic & Medicinal …, 2014 - Elsevier
A series of 24 novel heterocyclic compounds—functionalized at position 4 with aldehyde (5a–
5f), carboxylic acid (6a–6f), nitrile (7a–7f) and oxime (8a–8f) functional groups—bearing 6 …
5f), carboxylic acid (6a–6f), nitrile (7a–7f) and oxime (8a–8f) functional groups—bearing 6 …
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- biological evaluation anhydrase inhibitors
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- carboxylate and sulfonate carbonic anhydrase
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- acetylcholinesterase inhibition carbonic anhydrase