[HTML][HTML] How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

SR Shaikh, JJ Kinnun, X Leng, JA Williams… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Marine long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic (EPA) and
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …

[HTML][HTML] Polyunsaturated fatty acid–cholesterol interactions: domain formation in membranes

SR Wassall, W Stillwell - Biochimica et Biophysica Acta (BBA) …, 2009 - Elsevier
Polyunsaturated fatty acids (PUFA) constitute an influential group of molecules that promote
health by an as yet unknown mechanism. They are structurally distinguished from less …

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …

All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA

X Leng, JJ Kinnun, AT Cavazos, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Eicosapentaenoic (EPA, 20: 5), docosahexaenoic (DHA, 22: 6) and
docosapentaenoic (DPA, 22: 5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) …

Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …

Novel NMR tools to study structure and dynamics of biomembranes

K Gawrisch, NV Eldho, IV Polozov - Chemistry and physics of lipids, 2002 - Elsevier
Nuclear magnetic resonance (NMR) studies on biomembranes have benefited greatly from
introduction of magic angle spinning (MAS) NMR techniques. Improvements in MAS probe …

Water permeability of polyunsaturated lipid membranes measured by 17O NMR

D Huster, AJ Jin, K Arnold, K Gawrisch - Biophysical journal, 1997 - cell.com
Diffusion-controlled water permeation across bilayers of polyunsaturated phospholipids was
measured by 17O nuclear magnetic resonance. In 100-nm extruded liposomes containing …

n− 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research

DWL Ma, J Seo, KC Switzer, YY Fan… - The Journal of nutritional …, 2004 - Elsevier
In recent years, our understanding of the plasma membrane has changed considerably as
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …

Docosahexaenoic acid domains: the ultimate non-raft membrane domain

SR Wassall, W Stillwell - Chemistry and physics of lipids, 2008 - Elsevier
What distinguishes polyunsaturated fatty acids (PUFAs) from less unsaturated fatty acids is
the presence of a repeating CH–CH2–CH unit that produces an extremely flexible structure …

Order from disorder, corralling cholesterol with chaotic lipids: The role of polyunsaturated lipids in membrane raft formation

SR Wassall, MR Brzustowicz, SR Shaikh… - Chemistry and physics …, 2004 - Elsevier
A myriad of health benefits including the prevention of cancer and heart disease
accompanies consumption of polyunsaturated fatty acids (PUFA). Of special importance is …