Cross-sectional studies show that higher blood concentrations of inflammatory markers tend
to be more common in frail older people, but longitudinal evidence that these inflammatory …

BACKGROUND: The immune and blood coagulation systems have been implicated in the
pathophysiology of the geriatric syndrome of frailty, but limited prospective data examining …

Background Systemic inflammation has been linked to diseases and frailty. However, little is
known about the effect of systemic inflammation on frailty progression with a longitudinal …

Frailty is associated with a pro-inflammatory state, which has been characterized by
elevated levels of systemic inflammatory biomarkers, but has not been related to the number …

The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Background Previous studies demonstrated associations between IL-6 and frailty, but
associations between a wide range of cytokines, chemokines, and growth factors with …

Background Upregulation of pro-inflammatory cytokines has not only been associated with
increased morbidity and mortality in older adults but also has been linked to frailty. In the …

Background Evidence suggests that systemic inflammation may have a mechanistic role in
age-related frailty, yet prospective data is limited. We examined whether systemic …

Chronic inflammation is a well-established background process in many age-related
diseases. Many recent studies investigate the use of various inflammatory biomarkers such …

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors,
leading to a higher risk of negative health-related outcomes.“Inflammaging”, an age-related …