[HTML][HTML] RAGE pathway activation and function in chronic kidney disease and COVID-19

CS Curran, JB Kopp - Frontiers in Medicine, 2022 - frontiersin.org
The multi-ligand receptor for advanced glycation end-products (RAGE) and its ligands are
contributing factors in autoimmunity, cancers, and infectious disease. RAGE activation is …

[HTML][HTML] RAGE signaling regulates the progression of diabetic complications

K Taguchi, K Fukami - Frontiers in Pharmacology, 2023 - frontiersin.org
Diabetes, the ninth leading cause of death globally, is expected to affect 642 million people
by 2040. With the advancement of an aging society, the number of patients with diabetes …

The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease

A Gugliucci, T Menini - Oxidative Stress and Inflammation in Non …, 2014 - Springer
Chronic kidney disease (CKD) has been shown to be associated with high oxidative stress
and cardiovascular disease. In this chapter our focus will be on the role of advanced …

[HTML][HTML] Receptor for advanced glycation endproducts (RAGE), its ligands, and soluble RAGE: potential biomarkers for diagnosis and therapeutic targets for human …

EJ Lee, JH Park - Genomics & informatics, 2013 - ncbi.nlm.nih.gov
Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able
to bind several different ligands, including advanced glycation endproducts, high-mobility …

Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives

S Chiappalupi, L Salvadori, A Vukasinovic, R Donato… - Life Sciences, 2021 - Elsevier
A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global …

[HTML][HTML] Hyperactivated RAGE in comorbidities as a risk factor for severe COVID-19—The role of RAGE-Ras crosstalk

S Chiappalupi, L Salvadori, R Donato, F Riuzzi, G Sorci - Biomolecules, 2021 - mdpi.com
The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a
role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has …

AGE/RAGE in diabetic kidney disease and ageing kidney

XQ Wu, DD Zhang, YN Wang, YQ Tan, XY Yu… - Free Radical Biology …, 2021 - Elsevier
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

RAGE and the pathogenesis of chronic kidney disease

V D'agati, AM Schmidt - Nature Reviews Nephrology, 2010 - nature.com
The multiligand receptor of the immunoglobulin superfamily, receptor for advanced glycation
endproducts (RAGE), is a signal transduction receptor that binds advanced glycation …

[HTML][HTML] RAGE receptor: May be a potential inflammatory mediator for SARS-COV-2 infection?

M Kerkeni, J Gharbi - Medical Hypotheses, 2020 - ncbi.nlm.nih.gov
Knowledge of the pathophysiology of SARS-COV-2 has provided a strong stimulus to further
our understanding of the viral infection and its associated diseases. No data is available …

[HTML][HTML] The role of advanced glycation end products and its soluble receptor in kidney diseases

M Steenbeke, R Speeckaert, S Desmedt… - International Journal of …, 2022 - mdpi.com
Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic
inflammation, which may lead to an increase in the synthesis of advanced glycation end …