[HTML][HTML] Folliculin: a regulator of transcription through AMPK and mTOR signaling pathways
JMJ Ramirez Reyes, R Cuesta… - Frontiers in Cell and …, 2021 - frontiersin.org
Folliculin (FLCN) is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé
(BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein …
(BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein …
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
CS Petit, A Roczniak-Ferguson, SM Ferguson - Journal of Cell Biology, 2013 - rupress.org
Birt-Hogg-Dubé syndrome, a human disease characterized by fibrofolliculomas (hair follicle
tumors) as well as a strong predisposition toward the development of pneumothorax …
tumors) as well as a strong predisposition toward the development of pneumothorax …
[HTML][HTML] Nutrient signaling and lysosome positioning crosstalk through a multifunctional protein, folliculin
N de Martín Garrido, CHS Aylett - Frontiers in Cell and …, 2020 - frontiersin.org
FLCN was identified as the gene responsible for Birt-Hogg-Dubé (BHD) syndrome, a
hereditary syndrome associated with the appearance of familiar renal oncocytomas. Most …
hereditary syndrome associated with the appearance of familiar renal oncocytomas. Most …
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
M Baba, SB Hong, N Sharma… - Proceedings of the …, 2006 - National Acad Sciences
Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the
hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD …
hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD …
FLCN: the causative gene for Birt-Hogg-Dubé syndrome
LS Schmidt, WM Linehan - Gene, 2018 - Elsevier
Germline mutations in the novel tumor suppressor gene FLCN are responsible for the
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …
autosomal dominant inherited disorder Birt-Hogg-Dubé (BHD) syndrome that predisposes to …
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
C Di Malta, A Zampelli, L Granieri, C Vilardo… - EMBO Molecular …, 2023 - embopress.org
Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome
characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and …
characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and …
Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies
LS Schmidt - Familial cancer, 2013 - Springer
Since the hallmark dermatologic features of Birt–Hogg–Dubé (BHD) syndrome were first
described by three Canadian physicians in 1977, the clinical manifestations of BHD have …
described by three Canadian physicians in 1977, the clinical manifestations of BHD have …
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
Noncanonical mechanistic target of rapamycin (mTOR) pathways remain poorly understood.
Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a …
Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a …
[HTML][HTML] Tumor suppressor folliculin regulates mTORC1 through primary cilia
M Zhong, X Zhao, J Li, W Yuan, G Yan, M Tong… - Journal of Biological …, 2016 - ASBMB
Folliculin (FLCN) is the tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome
that predisposes patients to incident of hamartomas and cysts in multiple organs. Its …
that predisposes patients to incident of hamartomas and cysts in multiple organs. Its …
Identification and characterization of a novel folliculin-interacting protein FNIP2
Birt–Hogg–Dube'syndrome characterized by increased risk for renal neoplasia is caused by
germline mutations in the BHD/FLCN gene encoding a novel tumor suppressor protein …
germline mutations in the BHD/FLCN gene encoding a novel tumor suppressor protein …