An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient
construction of 2-(trifluoromethyl) quinazolin-4 (3 H)-ones has been developed. This …

Presented herein is a solvent-dependent selective synthesis of CF3-tethered indazole
derivatives via the cascade reactions of 1-arylpyrazolidinones with trifluoromethyl ynones …

A mild, two-step reaction for the synthesis of 6-trifluoromethylindolo [1, 2-c] quinazolines
from readily available indoles and N-(2-iodophenyl) trifluoroacetimidoyl chlorides via …

Presented herein is a selective synthesis of 3‐(α‐fluorovinyl) indoles and 3‐acylindoles via
the coupling of 1‐phenylpyrazolidinones with α, α‐difluoromethylene alkynes …

A low cost FeCl3‐mediated cascade annulation of trifluoroacetimidoyl chlorides and
hydrazides for the efficient synthesis of 5‐trifluoromethyl‐1, 2, 4‐triazoles has been …

A palladium-catalyzed three-component carbonylative reaction of trifluoroacetimidoyl
chlorides and amines for the synthesis of valuable 2-(trifluoromethyl) quinazolin-4 (3H)-ones …

A set of reactions involving copper-catalyzed trifluoromethylazidation and then
rearrangement of aniline-linked 1, 7-enynes with the relatively poorly reactive Togni reagent …

Three types of trifluoromethylated pyrazolidines, pyrazolines, and pyrazoles can be
synthesized via divergent reaction of β-CF3-1, 3-enyne with hydrazines. The reaction with …

Exploitation of effective methodologies to construct the pyridopyrimidinone scaffold
expediently has a significant impact on organic synthesis and drug development. Presented …

A transition-metal-free synthesis of quinazolin-4-ones by Cs2CO3-promoted SNAr reaction
of ortho-fluorobenzamides with amides followed by cyclization in dimethyl sulfoxide has …