Neutralizing Staphylococcus aureus virulence with AZD6389, a three mAb combination, accelerates closure of a diabetic polymicrobial wound

C Tkaczyk, O Jones-Nelson, YY Shi, DE Tabor… - Msphere, 2022 - Am Soc Microbiol
Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with
high morbidity and mortality despite current standard of care. Since Staphylococcus aureus …

Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing

J Goldufsky, SJ Wood, V Jayaraman… - Wound Repair and …, 2015 - Wiley Online Library
Diabetic foot ulcers are responsible for more hospitalizations than any other complication of
diabetes. Bacterial infection is recognized as an important factor associated with impaired …

Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds

EK White, A Uberoi, JTC Pan, JT Ort, AE Campbell… - Science …, 2024 - science.org
Chronic wounds are a common and costly complication of diabetes, where multifactorial
defects contribute to dysregulated skin repair, inflammation, tissue damage, and infection …

Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response

EA Grice, ES Snitkin, LJ Yockey… - Proceedings of the …, 2010 - National Acad Sciences
Diabetics frequently suffer from chronic, nonhealing wounds. Although bacterial colonization
and/or infection are generally acknowledged to negatively impact wound healing, the …

Neutralizing alpha-toxin accelerates healing of Staphylococcus aureus-infected wounds in nondiabetic and diabetic mice

RV Ortines, H Liu, LI Cheng, TS Cohen… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Staphylococcus aureus wound infections delay healing and result in invasive complications
such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal …

Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy

LR Kalan, JS Meisel, MA Loesche, J Horwinski… - Cell host & …, 2019 - cell.com
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing

G Wang, Z Lin, Y Li, L Chen, SK Reddy, Z Hu… - Advanced drug delivery …, 2023 - Elsevier
With the development of society and the improvement of life quality, more than 500 million
people are affected by diabetes. More than 10% of people with diabetes will suffer from …

[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies

SG Pereira, J Moura, E Carvalho… - Frontiers in …, 2017 - frontiersin.org
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …

Bad “staph” in the wound environment of diabetic foot ulcers

AS MacLeod - Cell Host & Microbe, 2019 - cell.com
Diabetic foot ulcers (DFUs) are a leading cause of high morbidity among diabetic patients. In
this issue of Cell Host & Microbe, Kalan et al.(2019) examine the microbial bio-burden of …

Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts

L Tuchscherr, È Korpos, H van de Vyver… - International Journal of …, 2018 - Elsevier
Staphylococcus aureus is the most frequent pathogen causing diabetic foot infections. Here,
we investigated the degree of bacterial virulence required to establish invasive tissue …