Neutralizing Staphylococcus aureus virulence with AZD6389, a three mAb combination, accelerates closure of a diabetic polymicrobial wound
C Tkaczyk, O Jones-Nelson, YY Shi, DE Tabor… - Msphere, 2022 - Am Soc Microbiol
Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with
high morbidity and mortality despite current standard of care. Since Staphylococcus aureus …
high morbidity and mortality despite current standard of care. Since Staphylococcus aureus …
Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing
J Goldufsky, SJ Wood, V Jayaraman… - Wound Repair and …, 2015 - Wiley Online Library
Diabetic foot ulcers are responsible for more hospitalizations than any other complication of
diabetes. Bacterial infection is recognized as an important factor associated with impaired …
diabetes. Bacterial infection is recognized as an important factor associated with impaired …
Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds
Chronic wounds are a common and costly complication of diabetes, where multifactorial
defects contribute to dysregulated skin repair, inflammation, tissue damage, and infection …
defects contribute to dysregulated skin repair, inflammation, tissue damage, and infection …
Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response
Diabetics frequently suffer from chronic, nonhealing wounds. Although bacterial colonization
and/or infection are generally acknowledged to negatively impact wound healing, the …
and/or infection are generally acknowledged to negatively impact wound healing, the …
Neutralizing alpha-toxin accelerates healing of Staphylococcus aureus-infected wounds in nondiabetic and diabetic mice
Staphylococcus aureus wound infections delay healing and result in invasive complications
such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal …
such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal …
Strain-and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy
Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …
Colonizing microbiota is associated with clinical outcomes in diabetic wound healing
G Wang, Z Lin, Y Li, L Chen, SK Reddy, Z Hu… - Advanced drug delivery …, 2023 - Elsevier
With the development of society and the improvement of life quality, more than 500 million
people are affected by diabetes. More than 10% of people with diabetes will suffer from …
people are affected by diabetes. More than 10% of people with diabetes will suffer from …
[HTML][HTML] Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies
World Health Organization considered diabetes as one of the 20th century epidemics,
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …
estimating that over 10% of the world population is diabetic or at high risk. Self-assessment …
Bad “staph” in the wound environment of diabetic foot ulcers
AS MacLeod - Cell Host & Microbe, 2019 - cell.com
Diabetic foot ulcers (DFUs) are a leading cause of high morbidity among diabetic patients. In
this issue of Cell Host & Microbe, Kalan et al.(2019) examine the microbial bio-burden of …
this issue of Cell Host & Microbe, Kalan et al.(2019) examine the microbial bio-burden of …
Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts
L Tuchscherr, È Korpos, H van de Vyver… - International Journal of …, 2018 - Elsevier
Staphylococcus aureus is the most frequent pathogen causing diabetic foot infections. Here,
we investigated the degree of bacterial virulence required to establish invasive tissue …
we investigated the degree of bacterial virulence required to establish invasive tissue …