Exposure to stress activates the hypothalamic–pituitary–adrenal axis and leads to increased
levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal …

An abnormality in adaptation to negative life events is considered as one of the main causes
of the development of depressive symptoms. According to the corticosteroid receptor …

Mood and anxiety disorders are considered stress‐related diseases characterized by an
impaired function of mineralocorticoid and glucocorticoid receptors (MR and GR …

Major depression is thought to originate from the interaction between susceptibility genes
and adverse environmental events, in particular stress. The hypothalamus–pituitary–adrenal …

Stress represents the main environmental risk factor for mental illness. Exposure to stressful
events, particularly early in life, has been associated with increased incidence and …

The article discusses the research which shows that FKBP5 gene variants alter risk for
psychiatric disorder after childhood trauma. It states that the gene strongly induced following …

The FKBP5 gene codifies a co-chaperone protein associated with the modulation of
glucocorticoid receptor interaction involved in the adaptive stress response. The FKBP5 …

The brain is a central hub for integration of internal and external conditions and, thus, a
regulator of the stress response. Glucocorticoids are the essential communicators of this …

Stress is a state of derailed homeostasis and a main environmental risk factor for psychiatric
diseases. Chronic or uncontrollable stress may lead to a dysregulation of the hypothalamic …

The FK 506 binding protein 51 or FKBP5 has been implicated in the regulation of
glucocorticoid receptor (GR) sensitivity, and genetic variants in this gene have been …