Neurovascular glial unit: A target of phytotherapy for cognitive impairments

L Chen, Y Zhen, X Wang, J Wang, G Zhu - Phytomedicine, 2023 - Elsevier
Background Neurovascular glial unit (NVGU) dysfunction has been reported to be an early
and critical event in the pathophysiology of Alzheimer's disease (AD) and vascular dementia …

Ginkgolide B Alleviates Learning and Memory Impairment in Rats With Vascular Dementia by Reducing Neuroinflammation via Regulating NF-κB Pathway

L Huang, Y Shi, L Zhao - Frontiers in pharmacology, 2021 - frontiersin.org
Ginkgobalide B (GB) as the main active ingredient of traditional Chinese medicine Ginkgo
biloba extract is reported to reduce neuroinflammation, protect neurons and promote …

Comprehensive Exploration of the Neuroprotective Mechanisms of Ginkgo biloba Leaves in Treating Neurological Disorders

Q Liu, J Wang, Z Gu, T Ouyang, H Gao… - The American Journal …, 2024 - World Scientific
Neurological disorders (NDs) are diseases that seriously affect the health of individuals
worldwide, potentially leading to a significant reduction in the quality of life for patients and …

Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled …

T Nakase, Y Tatewaki, I Matsudaira, K Kobayashi, H Iki… - Plos one, 2023 - journals.plos.org
Background and purpose Ginkgo biloba extract (GBE) reportedly ameliorates cognitive
function in patients with chronic cerebrovascular insufficiency. However, its efficacy in …

Similarity of therapeutic networks induced by a multi-component herbal remedy, Ukgansan, in neurovascular unit cells

BY Kim, HS Lim, YJ Kim, E Sohn, YH Kim, I Koo… - Scientific reports, 2020 - nature.com
The neurovascular unit, which includes neurons, glial cells, and vascular cells, plays crucial
roles in the onset and progression of Alzheimer's disease (AD). Therefore, effective drugs …

[HTML][HTML] Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier

M Kim, H Mok, WS Yeo, JH Ahn, YK Choi - Journal of ginseng research, 2021 - Elsevier
Ginseng has long been considered as an herbal medicine. Recent data suggest that
ginseng has anti-inflammatory properties and can improve learning-and memory-related …

Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro …

X Yang, T Zheng, H Hong, N Cai, X Zhou, C Sun… - Frontiers of …, 2018 - Springer
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized
by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence …

Multiple mechanistic models reveal the neuroprotective effects of diterpene ginkgolides against astrocyte-mediated demyelination via the PAF-PAFR pathway

TJ Wang, ZY Wu, CH Yang, L Cao… - The American Journal …, 2022 - World Scientific
Currently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo
components, have potential benefits for ischemic stroke patients, but there is little evidence …

Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion

J Huang, J Yang, X Zou, S Zuo… - Experimental …, 2021 - journals.sagepub.com
White matter lesion (WML) is caused by chronic cerebral hypoperfusion, which are usually
associated with cognitive impairment. Evidence from recent studies has shown that …

[HTML][HTML] Ginkgo biloba L. extract protects against chronic cerebral hypoperfusion by modulating neuroinflammation and the cholinergic system

MS Kim, JH Bang, J Lee, JS Han, TG Baik, WK Jeon - Phytomedicine, 2016 - Elsevier
Background Ginkgo biloba extract (GBE)—a widely used nutraceutical—is reported to have
diverse functions, including positive effects on memory and vasodilatory properties …