Severe malaria is a medical emergency. It is a major cause of preventable childhood death
in tropical countries. Severe malaria justifies considerable global investment in malaria …

Background About 90 percent of the deaths from malaria are in African children, but criteria
to guide the recognition and management of severe malaria have not been validated in …

Falciparum malaria remains a major killer in developing countries, particularly for African
children. The sequestration of parasitized erythrocytes in the deep microvasculature is …

OBJECTIVE. Although the greatest morbidity and mortality attributable to malaria occurs
among children in Africa, up to one third of the world's malaria burden is borne by non …

Background. Data from the largest randomized, controlled trial for the treatment of children
hospitalized with severe malaria were used to identify such predictors of a poor outcome …

Background Malaria continues to claim one to two million lives a year, mainly those of
children in sub-Saharan Africa. Reduction in mortality depends, in part, on improving the …

Summary The Severe Malaria in African Children (SMAC) network was established to
conduct mortality-based trials. Although falciparum malaria kills more than one million …

Background: Early recognition of children at highest risk of dying and the targeting of
appropriate drug therapy are vital to the improvement of paediatric care in developing …

Bacteraemia associated with severe malaria in childhood is a sporadically reported
phenomenon but its incidence and clinical importance are unknown. We have reviewed …

The symptoms of severe malaria and their contribution to mortality were assessed in 290
children in northern Ghana. Common symptoms were severe anemia (55%), prostration …