Host PDZ‐containing proteins targeted by SARS‐CoV‐2

C Caillet‐Saguy, F Durbesson, VV Rezelj… - The FEBS …, 2021 - Wiley Online Library
Small linear motifs targeting protein interacting domains called PSD‐95/Dlg/ZO‐1 (PDZ)
have been identified at the C terminus of the severe acute respiratory syndrome coronavirus …

[HTML][HTML] The envelope (E) protein of SARS-coV-2 as a pharmacological target

T Santos-Mendoza - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern.
Several spike (S) protein-based vaccines have been developed that efficiently protect the …

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated …

A Toto, S Ma, F Malagrinò, L Visconti, L Pagano… - Protein …, 2020 - Wiley Online Library
The Envelope protein (E) is one of the four structural proteins encoded by the genome of
SARS‐CoV and SARS‐CoV‐2 Coronaviruses. It is an integral membrane protein, highly …

[HTML][HTML] New strategy for COVID-19: an evolutionary role for RGD motif in SARS-CoV-2 and potential inhibitors for virus infection

S Yan, H Sun, X Bu, G Wan - Frontiers in Pharmacology, 2020 - frontiersin.org
In December 2019, a pneumonia outbreak termed COVID-19 by WHO occurred in Wuhan,
Hubei province, China (Chan et al., 2020). By 30 May 2020, the pandemic had caused over …

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

J van de Leemput, Z Han - Molecular and cellular biology, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic, responsible for millions of deaths globally. Even with effective vaccines, SARS …

[HTML][HTML] The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis

JM Jimenez-Guardeño, JL Nieto-Torres… - PLoS …, 2014 - journals.plos.org
A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the
envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif …

An overview of human proteins and genes involved in SARS-CoV-2 infection

Z Jahanafrooz, Z Chen, J Bao, H Li, L Lipworth, X Guo - Gene, 2022 - Elsevier
As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-
CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally …

Essential functional molecules associated with SARS-CoV-2 infection: Potential therapeutic targets for COVID-19

K Rajarshi, R Khan, MK Singh, T Ranjan, S Ray, S Ray - Gene, 2021 - Elsevier
The whole world is still suffering substantially from the coronavirus disease 2019 (COVID-
19) outbreak. Several protein-based molecules that are associated with the Severe acute …

[HTML][HTML] Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Structural comparison and drug screening of spike proteins of ten SARS-CoV-2 variants

Q Yang, X Jian, AAS Syed, A Fahira, C Zheng, Z Zhu… - Research, 2022 - spj.science.org
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has evolved many
variants with stronger infectivity and immune evasion than the original strain, including …