Overcoming endocrine resistance in breast cancer
Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …
[HTML][HTML] Mechanisms of endocrine therapy resistance in breast cancer
F Rasha, M Sharma, K Pruitt - Molecular and cellular endocrinology, 2021 - Elsevier
The most commonly diagnosed breast cancer (BC) subtype is characterized by estrogen
receptor (ER) expression. Treatment of this BC subtype typically involves modalities that …
receptor (ER) expression. Treatment of this BC subtype typically involves modalities that …
Pathways to endocrine therapy resistance in breast cancer
Breast cancers with positive expression of Estrogen Receptor (ER+) are treated with anti-
hormone/endocrine therapy which targets the activity of the receptor, the half-life of the …
hormone/endocrine therapy which targets the activity of the receptor, the half-life of the …
Unraveling the mechanisms of endocrine resistance in breast cancer: new therapeutic opportunities
S Massarweh, R Schiff - Clinical Cancer Research, 2007 - AACR
Two thirds of breast cancers express the estrogen receptor (ER), which contributes to tumor
development and progression. ER-targeted therapy is therefore widely used in breast …
development and progression. ER-targeted therapy is therefore widely used in breast …
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies
O Saatci, KT Huynh-Dam, O Sahin - Journal of Molecular Medicine, 2021 - Springer
Abstract Estrogen receptor-positive (ER+) breast cancer accounts for approximately 75% of
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …
Biological mechanisms and clinical implications of endocrine resistance in breast cancer
Endocrine therapy represents the first and most efficacious targeted treatment for women
with estrogen receptor-positive (ER+) breast cancer. In the last four decades several …
with estrogen receptor-positive (ER+) breast cancer. In the last four decades several …
[HTML][HTML] Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer
M Zhao, B Ramaswamy - World journal of clinical oncology, 2014 - ncbi.nlm.nih.gov
The estrogen receptor (ER) pathway plays a critical role in breast cancer development and
progression. Endocrine therapy targeting estrogen action is the most important systemic …
progression. Endocrine therapy targeting estrogen action is the most important systemic …
Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals
M Szostakowska, A Trębińska-Stryjewska… - Breast Cancer Research …, 2019 - Springer
Introduction The majority of breast cancers (BCs) are characterized by the expression of
estrogen receptor alpha (ERα+). ERα acts as ligand-dependent transcription factor for genes …
estrogen receptor alpha (ERα+). ERα acts as ligand-dependent transcription factor for genes …
Mechanisms of endocrine resistance in breast cancer
CK Osborne, R Schiff - Annual review of medicine, 2011 - annualreviews.org
The estrogen receptor (ER) pathway plays a pivotal role in breast cancer development and
progression. Endocrine therapy to block the ER pathway is highly effective, but its …
progression. Endocrine therapy to block the ER pathway is highly effective, but its …
Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy
A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019 - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …
in both breast cancer (BC) development and progression. The treatment of choice in women …
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